This WHO module is addressed to health personnel responsible for malaria control at national and sub-national levels of the health care system. It requires some basic knowledge, but the main objective of this module is to inform professionals of new elements in combination therapies and methods of drug policy formulations. Combination therapies for malaria are increasingly being taken as best alternatives in countries where there is extensive resistance to antimalarial drugs -to a level where the drugs have no more effect in reducing mortality or morbidity. It should therefore facilitate a better understanding of the current antimalarial treatments, their selection in different epidemiological and socio-economic circumstances; and accordingly of changing or revising drug policies. The module consists of two parts: the Learner's guide; and the Tutor's guide.